[HTML][HTML] Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca2+-channel
The bronchodilator effects of Roflumilast “a selective phosphodiesterase type-4 (PDE4)”
inhibitor studied in this experimental protocol. The spiral strips of isolated guinea-pig
tracheal chains mounted in organ bath and maintained in Krebs solution ventilated with
carbogen at 32° C and in Ca++ restricted krebs solution. PDE inhibitory activity was
evaluated by recording dose response curves using inhibitory effect of isoprenaline on CCh
induced contractions. For confirmation of PDE inhibition the intracellular cAMP levels were …
inhibitor studied in this experimental protocol. The spiral strips of isolated guinea-pig
tracheal chains mounted in organ bath and maintained in Krebs solution ventilated with
carbogen at 32° C and in Ca++ restricted krebs solution. PDE inhibitory activity was
evaluated by recording dose response curves using inhibitory effect of isoprenaline on CCh
induced contractions. For confirmation of PDE inhibition the intracellular cAMP levels were …
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